Research Initiatives
NBRL-IIT Kharagpur, keeps a vision of "Translating Nanotechnology for Biotechnological Application" and continuously working in this aspect. Few of the initiatives are as:
Regenerative Medicine
3D Bioprinted Resorbable Cardiovascular Stent
NBRL is actively developing nanoengineered 3D printed thinner bioresorbable for controlled degradation, ffficient endothelialization, antithrombotic, and antiproliferation of vascular smooth muscle cells to treat atherosclerosis:3DNanoResStent.
This work is funded by ICMR.
Hospital Collaborator: SCTIMST, Thiruvananthapuram
3D Bioprinted Microneedle-Hydrogel System for Second Degree Burn Management
NBRL is actively developing 3D Printed bioresorbable microneedle array-based sutureless breathable dermal-substitute system for second-degree burn wounds to treat microbial infection, hypertrophic scar, and with skin regenerative properties (3DBioResMiNee).
This work is funded by ICMR.
Hospital Partner: SCTIMST, Thiruvananthapuram
Acne Patches
NBRL is developing bioinspired multifunctional nanostructured hydrogel of hyaluronic acid and carboxymethyl cellulose as a dry and thin acne patch.
Extracellular Vesicles for Diabetic Wound Management
NBRL is developing bioresorbable, breathable hydrogel enriched with drug-loaded extracellular vesicles for diabetic wounds to treat microbial infection, inflammation, scar, along with dermal-remodeling, regeneration, and angiogenesis properties (ExoHydroHeal). This work is proposed fur funding to ICMR.
Hospital Collaboration: ILBS, New Delhi
Nanofibers for Biomedical Applications
NBRL is constantly developing biomedical applications of nanofibers e.g. scaffolds, vascular tissue engineering, bone tissue engineering, biosensors, drug delivery, ECM biomimicking, and wound healing.
Lipid Nanomaterials for Cancer Therapeutics
NBRL is developing Lipid Nanomaterials liposomes, lipid nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and lipid-polymer hybrid nanoparticles for therapeutics enhancement in cancer.
Drug Delivery
NBRL is developing ligand functionalized nano-formulation for the targeted delivery of Everolimus in non-cancerous neuroendocrine tumours of pituitary, lung and pancreas. Funded by SRIC-IITKGP
Injectable Gel for Bone Regeneration
NBRL is developing thermoresponsive hydrogel for long sustained delivery of peptide and drug for bone regeneration. NBRL is also developing human bone mimetic 3D Bio-printed organoid models for drug / toxicology screening. Funded by SPARC, MoE, Govt. of India.
Collaborator: CSIR-CDRI & Johns Hopkins University, USA
Sensors & Devices
Batteryless & Leadless Cardiac Pacemaker
NBRL is developing 3D Printed self-driven, leadless cardiac pacemaker for managing bradycardia (3DNanoCarPaM). The work is proposed for funding to ICMR.
Hospital Collaborator: SCTIMST, Thirivananthapuram
Ease by Use Device for Sensing Applications
NBRL is developing colorimetric and fluorescent device for detection of several biomarkers. NBRL is also developing affordable point-of-care solutions.
Sensor for Sports Applications
NBRL is developing ease-by-use sensors for sports application in which sportsman can have the analysis in real-time using ultrasensitive and ultraselective nanomaterials.
Heavy Metal Detection
NBRL is working in the ultrasensitive and ultraselective nanomaterials for heavy metal detection and quantification.
Food & Nutraceuticals
Nutraceutical Delivery
NBRL is making significant strides in the field of nutraceutical delivery, focusing on innovative methods to enhance the bioavailability and efficacy of nutraceuticals. NBRL is focusing to the creation of advanced delivery systems that ensure optimal absorption and sustained release of nutrients. By integrating cutting-edge technology with a deep understanding of nutritional science, NBRL aims to improve health outcomes and provide effective solutions for various health challenges.
3D Printed Foods
NBRL is working towards the advancements in 3D printed foods, revolutionizing the approaches for nutrition and culinary innovation. NBRL focuses on developing sustainable, customizable, and nutrient-rich food solutions using cutting-edge 3D printing technology. By integrating scientific expertise with creative design, we aim to enhance food security, reduce waste, and provide personalized nutrition options. NBRL is paving the way for a future where food production is more efficient, accessible, and tailored to individual dietary needs.
Processing and Efficacy
NBRL is working to enhance the efficiency of food processing techniques, such as extraction and separation using nanotechnology.
Packaging
NBRL is developing sustainable packaging for food materials which will have potential to contribute towards less plastic uses. NBRL is developing sustainable solution for enhanced food packaging via a science-based composite blend of natural-sourced polymers and extracellular polymeric substance.
Agriculture and Sustainability
Nanofertilizer, Photosynthesis / Growth Enhancers
NBRL is taking initiatives in the domain of agricultural innovation with the work on nanofertilizers, including Nano-NPK and nano-sized photosynthesis enhancers. Research focuses on developing efficient, sustainable, and eco-friendly solutions to enhance crop yield and nutrient uptake. By leveraging nanotechnology, NBRL aims to optimize fertilizer use, reduce environmental impact, and improve plant health; also paving the way for a more sustainable and productive agricultural future.
Waste Valorization
NBRL is working in waste valorization, transforming waste materials into valuable resources. Innovative approaches focus on converting agricultural, hospital, industrial, and municipal waste into useful products such as biomaterials, fluorescent materials, cosmeceuticals, fertilizers, and bioplastics. By integrating advanced technologies and sustainable practices, NBRL aims to reduce environmental impact, promote circular economy principles, and create economic opportunities. His contributions are driving the shift towards a more sustainable and resource-efficient future.
Water Quality Management
NBRL is working towards advancements in water quality management through the use of innovative nanomaterials. The work focuses on developing efficient and sustainable solutions to purify and treat water, removing contaminants and improving overall water quality. By leveraging the unique properties of nanomaterials, NBRL aims to address critical water challenges, ensuring safe and clean water for communities.
Air Quality Management
NBRL is working on developing polymer / polymer-nanoparticles composites for air quality management.
NBRL is engineer air filters by tuning surface morphology, physical, chemical, and thermal characteristics of the nanocomposites to achieve sub micron and nano sized pollutant and including microbial filtration.
Toxicology: Risk Assessment & Management
Toxicology & Biocompatibility
NBRL is actively working in toxicology and biocompatibility, focusing on the safe application of nanomaterials, biomaterials, scaffolds, and implants in biomedical fields. NBRL is involved in assessing the interactions between nanomaterials and biological systems to ensure their safety and efficacy. NBRL aims to advance medical treatments while minimizing potential risks by developing innovative risk assessment methods and biocompatible nanomaterials.
Metal & Novel Chemical Risk Identification/Management
NBRL is working in the field of metal and novel chemical risk identification and management. NBRL focuses on assessing the environmental and health impacts of various nanomaterials and chemicals. By developing advanced risk assessment methodologies and management strategies, we aims to mitigate potential hazards associated with these substances. We contribute for ensuring the safe and sustainable use of nanotechnology and chemicals in various industries.
Mycotoxin Management
NBRL is working in mycotoxin management, focusing on innovative strategies to detect, control, and mitigate mycotoxin contamination in food and agricultural products and healthcare. NBRL involves developing advanced nanomaterials and biosensors for efficient mycotoxin detection and removal. By integrating cutting-edge technology with sustainable practices, we aim to enhance food safety and protect public health. His contributions are crucial for ensuring the safety and quality of food supplies.
Active Pharmaceuticals Identification/Mitigation
NBRL is working on the identification and mitigation of active pharmaceuticals in soil and water by developing advanced adsorption techniques using materials like activated carbon and bentonite to remove pharmaceutical residues from wastewater. By integrating innovative methodologies and sustainable practices, we aim to reduce environmental contamination and promote safer water and soil quality.